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Mitochondrial protein misfolding can trigger the mitochondrial unfolded protein response, which is closely linked to ISR pathway activation
Some folks may start taking vitamin B12 to boost energy levels or address perceived deficiencies without first consulting a healthcare provider

For vegetarians, fortified plant-based products and supplements are vital options

Reactive oxygen and nitrogen species (ROS/RNS) from activated macrophages further exacerbate calcium handling defects

Inspection of the BMI % phenotype revealed a heavy tailed distribution, so we further quality controlled the BMI % phenotype to remove outlier participants with BMI changes above 20% or below 45% (Extended Data Fig
