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In addition to the requirements of safety, specificity, stability and high bioavailability, high BBB permeability is a necessary condition for Nrf2 activators to enter clinical application
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Mutations in the PCBD1 gene and the QDPR gene are causes of a family of disorders termed tetrahydrobiopterin deficiency syndromes
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(2) Sarin exerts toxicity by irreversibly inhibiting acetylcholinesterase (AChE), resulting in accumulation of acetylcholine at cholinergic synapses and subsequent neuromuscular and respiratory dysfunction
doi: 10.1155/2013/731023 38 LiangJRanYHuCZhouJYeLSuWet al
