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Do not breastfeed during treatment with pemetrexed for injection and for 1 week after the last dose

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IL-6 signalling exhibits both pro- and anti-inflammatory properties: it initially promotes the differentiation of macrophages and T- and B-lymphocytes, and later contributes to the resolution of inflammation 57

This means oral supplementation with crystalline B12 can be effective even when food-bound B12 absorption is impaired