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doi: 10.1038/nature09114 47

PMID 30296999

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Neutrophils in hyperglycemic conditions are triggered to produce S100 calcium-binding protein A8/A9 which binds to the receptors of Kupffer cells to enhance the production of thrombopoietin, which in turn interacts with c-MPL receptor on megakaryocytes and bone marrow progenitor cells to increase the proliferation resulting in reticulated thrombocytosis [39]

For example, treatment with QiDiTangShen granules significantly alleviated renal injury, improved renal function, and restored intestinal barrier in DN mice
