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This difference corresponded to the decrease in levels of the Anpep-catalyzed products (cysteine and glycine) compared with serum and urine from control rats (Figures 3D,E, metabolite determination results are shown in Supplementary Tables S10)

[Google Scholar] Pro-and antitumor effects of mitochondrial reactive oxygen species

Adding to this tension, recent negative clinical trials of iron chelators in degenerative diseases where ferroptosis has been implicated have tempered enthusiasm for iron-focused strategies and prompted a re-evaluation of irons true role in these diseases, and by extension, ferroptosis

Bray-Curtis dissimilarity analysis indicated substantial compositional divergence between groups (Figure S4A-B)