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3 The Schilling test also has fallen out of favor because it is complicated to perform, the radiolabeled vitamin B 12 is difficult to obtain, and interpretation of test results can be problematic in patients with renal insufficiency

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A population-based study in 3,884 elderly men and women with depressive disorders found that those with vitamin B 12 deficiency were almost 70% more likely to experience depression than those with normal vitamin B 12 status (98)

Experiments used the ESI ion spray source in positive and negative ion modes and hydrophilic interaction liquid chromatography