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When Hedgehog ligands bind with the receptors, the canonical Hedgehog signaling pathway is activated

Additionally, flavonoids upregulate enzymes like superoxide dismutase, catalase, glutathione peroxidase, and NAD(P)H: quinone oxidoreductase (NQO1)

Conflicts of Interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: the figures in the review except Figure 1 and Figure 2 were drawn by Figdraw

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These systems could be particularly valuable for chronic conditions requiring long-term therapy