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NSAIDs, colchicine, and glucocorticoids provide effective relief of inflammation and pain [132, 133]
Both compounds work by decreasing the mRNA expression of MMP-2, -9 and extracellular matrix metalloproteinase inducer (EMMPRIN), while increasing the expression of tissue inhibitors of metalloproteinases-1, -2 (TIMP-1, -2) and reversion-inducing cysteine-rich protein with Kazal motifs (RECK)

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doi: 10.1179/174313208X332959
