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Elevated circulating TMAO levels have been associated with decreased expression of sirtuin 1 (SIRT1), leading to increased oxidative stress

Upon activation, these inflammatory cells secrete key mediators - including TNF-, IL-1, and IL-6 -which both amplify inflammation and exert chemotactic effects, recruiting more immune cells to pulmonary sites

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[DOI] [PMC free article] [PubMed] [Google Scholar] 8.Stormorken E., Jason L.A., Kirkevold M

MSG also leads to cell apoptosis and necrosis by producing free radicals and breaking down DNA molecules