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The IGF-1R localizes at the cell membrane, in the cytoplasm and within the nucleus in normal breast tissue and the intracellular localization of the IGF-1R has prognostic significance for breast cancer

10.1038/s41589-022-01234-w 166 MaH.HeZ.ChenJ.ZhangX.SongP

In click-chemistry based PROTACs, the yield of the reaction depends on the linker to be incorporated (e.g., length, substitutions, binding position to the ligand) 174

It is uncertain where NAC interferes in the cascade of the inflammatory response

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