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The IGF-1R localizes at the cell membrane, in the cytoplasm and within the nucleus in normal breast tissue and the intracellular localization of the IGF-1R has prognostic significance for breast cancer

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10.1038/s41589-022-01234-w 166 MaH.HeZ.ChenJ.ZhangX.SongP

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In click-chemistry based PROTACs, the yield of the reaction depends on the linker to be incorporated (e.g., length, substitutions, binding position to the ligand) 174

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It is uncertain where NAC interferes in the cascade of the inflammatory response

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