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doi: 10.1186/s13148-021-01037-1 134 ZhangYChenJMiDLingJLiHHePet al

Although melanin cannot be totally removed, it may be regulated or bleached through a variety of treatments

More importantly, however, is to consider relative shifts in TW CCS N2, meas between a parent drug (or any precursor) and its corresponding metabolite rather than their absolute TW CCS N2, meas values: constant and discriminative relative mean shifts in TW CCS N2, meas values apparently exist as demonstrated for eight different phase I and II biotransformation which were not only obtained on precursor ion but also on fragment ion level

10.1016/j.bbadis.2016.07.008 37 HuX

Liver glutathione declines 35-50% in aged animals [7] , while brain glutathione drops by at least 50% over adult aging [8]