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Therefore, mitochondrial enhancers such as NAC might be best, not as treatments of acute mood episodes, but as add-on maintenance therapies to manage difficult-to-treat subsyndromal symptomsan area of great clinical need
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The final products of peroxisomal -oxidation can reach mitochondria after conjugation with carnitine trough carnitine octanoyltransferase (CrOT) (whose substrates are medium and long-chain fatty acyl-groups) or peroxisomal carnitine acetyltransferase (CrAT), which is more active toward short-chain acyl-CoAs [18, 66]
