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Loop diuretics (furosemide): Long-term use of these with Neurobion may reduce thiamine levels in the blood

It is therefore plausible that the function of compartment-specific stress responses, such as the UPR ER and HSR, may co-operate to overcome proteotoxicity

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Animal models employ a wide range of behavioral assays, biochemical endpoints, and tissue sampling strategies, making cross-study comparison inherently difficult

This model of MRP1, built long before the release of the Cryo-EM structure of human MRP1 40 , remains in adequacy with the published Cryo-EM structure, validating our choice of mutants