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Description
Heat shock transcription factor 1 (HSF1) is a master regulator of proteostasis 30,31,32 which was recently reported to promote proteostasis and the regenerative activity of HSCs in response to culture stress and aging 33
In particular, SSRIs like sertraline (Zoloft) and escitalopram (Lexapro) frequently rank among the top prescriptions for depression and anxiety
The rapamycin-binding domain of the protein kinase mammalian target of rapamycin is a destabilizing domain

Edaravone (MCI-186) ALS 19 Study Group, 2017b
Koenig JE, Spor A, Scalfone N, Fricker AD, Stombaugh J, Knight R, et al
