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Heat shock transcription factor 1 (HSF1) is a master regulator of proteostasis 30,31,32 which was recently reported to promote proteostasis and the regenerative activity of HSCs in response to culture stress and aging 33

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In particular, SSRIs like sertraline (Zoloft) and escitalopram (Lexapro) frequently rank among the top prescriptions for depression and anxiety

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The rapamycin-binding domain of the protein kinase mammalian target of rapamycin is a destabilizing domain

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Edaravone (MCI-186) ALS 19 Study Group, 2017b

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Koenig JE, Spor A, Scalfone N, Fricker AD, Stombaugh J, Knight R, et al

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