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Phillips MC

Discussion over marijuana's inclusion on WADA's list of banned substances dates back two decades

An alternate possibility is that the acidic conditions mediated by the P protein favor the normal biogenesis of melanosomes, including the correct targeting of other melanosomal proteins such as tyrosinase.51 Single nucleotide polymorphisms in the first intron of OCA2 are the major determinant of brown versus blue iris color,52 and a germ line polymorphism of the OCA2 gene is associated with favorable survival of estrogen receptor-negative breast cancer.53 Conceivably this finding may be related to the previously reported enhanced sensitivity of cells overexpressing P protein to cytotoxic agents.54 In African and African-American individuals, there is a distinct OCA2 phenotype (Fig

doi: 10.1016/s0891-5849(99)00177-x

This type has been most frequently reported arising on the dorsum of the foot [16]