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By attaching a larger molecule, like a polyethylene glycol (PEG) chain (a process called PEGylation), scientists can make the peptide too large to be easily filtered by the kidneys and can also sterically hinder the approach of degrading enzymes

PMID:22304503

Neuropeptide Y (NPY) Y2 receptor-selective agonist inhibits food intake and promotes fat metabolism in mice: Combined anorectic effects of Y2 and Y4 receptor-selective agonists

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Statin medications are typically used as first-line cholesterol-lowering treatment (unless contraindicated) based on individualized cardiovascular risk assessment and LDL cholesterol levels (Whitlatch 2015