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Nonetheless, observational studies demonstrate decreases in certain plasmalogen species in Alzheimers disease, suggesting a probable link between ether lipids and aging-related pathologies (Grimm et al., 2011

These observed sex-dependent differences have been attributed to sex-dependent metabolic alterations such as the estrogen-dependent synthesis of phosphatidylcholines 88,89,90,91

2 and 3 of the ESM)

Insufficient sleep leads to increased free radical production, reduced antioxidant enzyme activity, and oxidative stress reactions

This critical reduction reaction is catalyzed by the enzyme ribonucleotide reductase (RNR)