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Dietary exposure of young mice to Mn (2400 ppm Mn in chow) significantly increased extracellular dopamine clearance, thus reducing the duration of dopamine in the synapse This was associated with locomotor hyperactivity and significant reductions in striatal DA, 3-MT, as well as 5-HT and 5-HIIA levels

This phenomena, and similar interactions of LTF with pathogenic organisms, have been well documented in multiple excellent separate reviews ( Conclusion In conclusion, LTF plays a major functional role in physiologic homeostasis as related to development of disease and associated pathology