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This is also supported by the fact that besides KIT and PTEN , mutations in PI3K and AKT homologous of PI3K-AKT-mTOR are scarce (4.8% PIK3CA , 3.8% PIK3CG , and 4.8% AKT3 ) ( 105)

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doi:10.1097/01.cmr.0000382797.99333.66

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The majority of chemically and physiologically unstable substances employed in pharmaceuticals were insoluble in aqueous solutions [156, 157]

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[DOI] [Google Scholar] 86.Le Collen L, Delemer B, Poitou C

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