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Inhibition of AGE system aids in preserving the homeostasis of the endoplasmic reticulum [91]

Another large study with 547 melanomas (including acral melanomas) treated with ipilimumab, however, showed no statistically significant difference of overall survival among melanoma subtypes [109]
Montgomery 2002, p
The microscope shows a smoker's melanosis to be characterized by a melanin hyperpigmentation of the lower part of the oral epithelium, similar to sun-tanned skin