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Conversely, tumors that have low immunogenicity can escape the immune system and undergo selective proliferation

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In contrast, a metabolic shift toward OXPHOS is often observed during lineage commitment and differentiation, as mitochondrial activity increases to meet the energy and biosynthetic demands of specialized cell types [189, 190]

This link, however, remains unproven

In contrast, our study set out to map the signaling events and adaptive pathways elicited by amino acid starvation in a non-transformed cell system, aiming to understand AA signaling and adaptation in the absence of oncogene-driven pathways