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Iimuro Y, Bradford BU, Yamashina S, Rusyn I, Nakagami M, Enomoto N et al

Overall, the ongoing advancement of therapeutic strategies for CRC, particularly within the framework of LS, underscores the necessity of personalized treatment modalities customized to the distinct genetic and molecular attributes of tumors, thereby enhancing patient outcomes and survival probabilities

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Israel Chaikoff, an observation now known as the Wolff-Chaikoff effect ( 3 and T 4 , this effect acts to block the excessive amounts of iodide in the body from generating large amounts of thyroid hormone ( However, the Wolff-Chaikoff effect is transient, usually lasting only one to two days, after which an escape occurs where regular synthesis of thyroid hormones resumes ( Notably, excess amounts of daily iodide ranging from 30 mg to 2 g are typically well tolerated in individuals with normal thyroid glands