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The hydroxyl and hydroperoxyl radicals are the eponyms of a family of Reactive Oxygen Species (ROS), which disruptively react with biological structures, such as unsaturated lipids of cellular membranes, the backbone and bases of DNA and essential chemical groups of catalytic and signaling proteins

Aging Cell 4 (3), 119125

framework substitutions are identified by methods well known in the art, e.g., by modeling of the interactions of the CDR and framework residues to identify framework residues important for antigen binding and sequence comparison to identify unusual framework residues at particular positions

10.1093/carcin/bgm123 171 SankarP.Gopal TelangA.KalaivananR.KarunakaranV.ManikamK.SarkarS

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