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Zhu adds, considering that keratinocytes are the major skin cell type in which HSV replicates in patients, the fact that acyclovir isnt all that potent at suppressing HSV in this cell type may explain why it isnt always effective in treating HSV flare-ups! Looking forward, the team is excited to follow up on some of their top antiviral candidates and keep developing their organoid models, whose utility in deciphering cell type-specific differences in antiviral effectiveness is now clear

Su et al., 2013

Neutrophils and platelets Neutrophils are key cells involved not only in acute but also in chronic inflammation

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Cureus, 14 (9), e28787