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(iii) U0126 (15 mg/kg)

The NADPH oxidase Nox4 has anti-atherosclerotic functions

12,13 Given that the replacement of some antioxidants can restore the immune cell response, potentially reducing the incidence or severity of viral pneumonia, it can be hypothesized that NAC, in addition to preventing damage caused by certain respiratory viruses, can improve cellular immunity when it is compromised and can modulate the immune response responsible for the most serious complications of COVID-19

So, I wouldn't call them cosmetic transformations

On the one hand, ROS induce oxidative damage to cysteine residues within the MutS complex (MSH2-MSH6 heterodimer), specifically impairing its ATPase-dependent DNA mismatch recognition capacity