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Research findings: Animal studies demonstrated extended reproductive cycles in aged female rats

Each time a cell divides, telomeres shorten, eventually triggering cellular senescence or apoptosis - effectively limiting the replicative lifespan of normal somatic cells to approximately 50-70 divisions (the Hayflick limit)

Alterations in the microbial ecosystem associated with rheumatoid arthritis and spondyloarthritis have led to the gutjoint hypothesis, which postulates that these ecological changes cause immune dysfunction that contributes to the development of arthritis

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