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Consequently, these experimental outcomes are consistent with a model in which the ROS-MAPK/Erk1/2 pathway may play a crucial role in mediating the hepatocyte toxicity induced by excessive CGA

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Mechanism six: mitochondrial damage and energy failure Mitochondria are the downstream target of all preceding mechanisms and are uniquely vulnerable to both calcium overload and peroxynitrite

Abdominal obesity, independent from caloric intake, accounts for the development of intestinal tumors in Apc(1638N/+) female mice