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Rabe, C., Steenkamp, J.A., Joubert, E., Burger, J.F.W., Ferreira, D

[DOI] [PMC free article] [PubMed] [Google Scholar] 53.Jackson A

In pancreatic ductal carcinoma cells, suppression of GPx1 expression promoted ROS-induced Akt signaling (measured by Akt phosphorylation) to drive an epithelial-mesenchymal transition that is associated with enhanced tumor growth, whereas overexpression of GPx1 decreased the phenotypic changes in pancreatic ductal carcinoma cells by decreasing ROS-mediated pro-survival signaling in these cells [134]