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This hydrolysis was attributed to putative esterases and activity was confirmed for both culture supernatants as well as whole cells, however, the extracellular enzymes proved to be unstable

Funding: This work was supported by NIH Predoctoral Training Grants T32 AI007640 (M.J.B.) and T32 GM067543 (Y.K.)

Clinical studies have documented that patients with group A -hemolytic streptococcal tonsillopharyngitis have a greater incidence of bacteriologic failure when treated with sulfamethoxazole and trimethoprim injection than do those patients treated with penicillin, as evidenced by failure to eradicate this organism from the tonsillopharyngeal area

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If you are traveling or need to take a dose on the go, use a small cooler or insulated bag with ice packs to keep the medication cold