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Pol J Food Nutr Sci

It was shown that treatment with dried powdered ginger rhizome improved both allodynia and hyperalgesia by decreasing the inflammatory responses mediated by nitric oxide (NO), prostaglandin E2 (PGE2), thromboxane B2 (TXB2), and interleukin-1 (IL-1) in lipopolysaccharide (LPS)-stimulated macrophages in FMS model mice, indicating that macrophages may contribute to NPP through the release of pro-inflammatory mediators (56)

Cell 83 , 20592076.e6 (2023)

These PUFAs (and to a lesser extent the PUFAs of cholesterol esters and triglycerides in the lipoprotein core) are highly vulnerable to oxidation by free radical species, particularly hydroxyl radicals ( OH)