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Indian Journal of Pathology and Microbiology 2011 54:4 (671-682) Klaassen Z, Chen J, Dixit V, Tubbs RS, Shoja MM, Loukas M

These people have a rare disease called Trimethylaminuria, or TMAU

This can occur via the release of NE by local axons within the tissue and also by the delivery of SNS-derived NE through the circulation

In a 24-week trial in 62 overweight or obese women, 28 with PCOS and 34 without, a reduced-calorie, low-glycemic index diet significantly improved acne, menstrual regularity, and testosterone and SHBG levels

In the presence of 100 M TMAO, PNU37883A was able to reverse the loss of contractile function, consistent with a TMAO concentration-dependent role for inducing Kir6.1 channel potentiation in dampening the contractile function in cardiomyocytes