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Hayashi CTH, Cao Y, Clark LC, Tripathi AK, Zavala F, Dwivedi G, et al

The definition of insulin resistance has always centered on glucose (30)

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Consult a healthcare provider before use if pregnant, nursing, taking medication, or have a medical condition

Additionally although signalling via growth factor receptors can be oncogenic the same receptors can also drive apoptosis within cancer cells ( IGF mutations do not occur frequently in cancer indicating that it is often not an initial driver of tumourigenesis (Simpson et al., 2017)