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Beyond direct antibacterial potency, the concept of synergistic selectivity emerges as a compelling clinical strategy: when combined with conventional antibiotics, clove phytochemicals can sensitize pathogens, allowing lower antibiotic doses to achieve equivalent or superior efficacy disarm, then treat, thereby expanding the therapeutic window and reducing host toxicity, an especially critical consideration for last-line drugs such as colistin

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Although currently not found to be directly linked to the activity of Grxs, ADP-ribosylation factor 6 is S-glutathionylated under ferroptotic conditions, regulating localization of the transferrin receptor on the cell membrane and transferrin uptake [131]