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Mechanical injury and hypoxia identified by injured surface mesothelium expressing podoplanin (PDPN)/mesothelin (MSLN) and upregulation of hypoxia-inducible factor 1 alpha (HIF1) are involved in the fibrotic process and the development of peritoneal adhesions suggested in an in vivo study (Tsai et al., 2018)

Previous research has demonstrated that deficit irrigation can save water while preserving marketable yield and even improving certain fruit quality characteristics, as long as soil moisture stays above a crucial physiological limit 4,5

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Additionally, clinics with experienced specialists and advanced facilities might have higher costs but could provide more effective and safe treatments

The CEPs allow for the transfer of load that is applied to the IVD and play an important role in the flow of nutrients/waste in and out of the IVD