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In another study, rats with diabetic kidney disease (DKD) were treated with a CD38 inhibitor, resulting in increased renal NAD + levels, which in turn decreased mitochondrial oxidative stress 144

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Abbreviations CT: Combined treatment SS: Single surgery JOA: Japanese Orthopaedic Association LDH: Lumbar disc herniation MIS-TILF: Minimally invasive transforaminal lumbar interbody fusion ODI: Oswestry Disability Index PEID: Percutaneous endoscopic interlaminar discectomy VAS: Visual Analog Scale VB12: Vitamin B12 RCT: Randomized controlled trial POD: Postoperative day TNF-: Tumor necrosis factor alpha IL: Interleukin PGE2: Prostaglandin E 2 CI: Confidence interval References Han J, Tang W, Li G, Ji X, Wu X, Zhu K, et al

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Tissue inhibitor of metalloproteinase-2 protection of matrix metalloproteinase-2 from degradation by plasmin is reversed by divalent cation chelator EDTA and the bisphosphonate alendronate

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Endokrynol Pol 72(2):153162

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