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Abbreviations ATP7B P-type adenosine triphosphatase CL Cardiolipin DNMTs DNA methyltransferase MBDs Metal-binding domains PA Phosphatidic acid SAH S -adenosylhomocysteine SAM S -adenosylmethionine TGN Trans -Golgi network WD Wilson disease Author Contributions Fei Wu and Jing Wang gathered the materials and wrote the preliminary draft

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