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L-cysteine is the predominant FeS cluster ligand in proteins across all extant life 61
In addition to the primary triggers of ferroptosis in OA (iron overload, mechanical overload, and inflammatory responses) discussed above, several other factors may further enhance ferroptosis in this context: (i) Elevated levels of ROS : These arise from mechanical stress, inflammatory responses and mitochondrial dysfunction, contribute significantly to ferroptosis by predisposing chondrocytes to oxidative damage, as these cells are particularly vulnerable to such stressors [126, 127, 128]
J Neurosci Res 84, 647654.CrossRefGoogle ScholarPubMed Drosophila melanogaster and Musca domestica is associated with oxidative stress
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Toxicity assessment of soil amended with tannery sludge, trivalent chromium and hexavalent chromium, using wheat, oat and sorghum plants
