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The enzyme also has a mitochondrial isoform that mediates the apoptotic response to oxidative stress49 and has a peroxidase independent structural role in sperm maturation.45, 50 GPx5 from both humans and rodents and Rodent GPx6 differ from other glutathione peroxidases in that their activities are independent of Selenium.51 This invariably implies that these forms of GPx may not be able to effectively scavenge H2O2, a feature which is characteristic of the selenium-dependent glutathione peroxidases.52 The clinical importance of GPx has been underlined by a number of studies

Trends Plant Sci 20:219229 Khan MIR, Palakolanu SR, Chopra P, Rajurkar AB, Gupta R, Iqbal N, Maheshwari C (2021) Improving drought tolerance in rice: ensuring food security through multi-dimensional approaches

Researchers have observed this protective effect through glutathiones activation of the Nrf2/HO-1 signaling pathway [4]

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One of the earliest neuroprotective agents investigated was memantine, an NMDA receptor antagonist designed to reduce glutamate-induced excitotoxicity