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This mutation increases the activity of glutathione S -transferase P1, resulting in the increased conjugation of hydrophobic and electrophilic compounds with glutathione, thus reducing their toxicity [23]

Current interventions for DILI include abstinence, N -acetylcysteine, corticosteroids, ursodeoxycholic acid, silymarin, glycyrrhizin, bile acid washouts, and emergency liver transplants [373]

309 , R1215R1225 (2015)

Our current understanding is that both, circulating IGF-I levels and locally produced IGF-I, contribute to the maintenance of microcirculation functional and structural integrity, increasing NO bioavailability, decreasing reactive oxygen species (ROS) production, and exerting antiinflammatory, antiapoptotic, and pro-angiogenic effects

However, as of now, research on the impact of MSM in these areas is still rare, and further exploration is needed in future studies