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In this model, ligation acts as (i) a mechanical trauma on the dentogingival area, thereby reducing tissue integrity and allowing for intense host-plaque interaction and (ii) a plaque-formation-promoting factor, thus increasing the number of bacteria

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Ethics Approval The study was approved by the competent authorities and applicable ethics committees of Czech Republic, Hungary, and Poland and was conducted in accordance with Good Clinical Practice guidelines and ethical standards as laid down in the 1964 Declaration of Helsinki

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