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Chronic low-grade inflammation further induces persistent microglial activation and polarization shifts, BBB endothelial dysfunction, and mitochondrial energy metabolism abnormalities, exacerbating neuronal damage [30]

In addition, it was found that IVC treatment improves the quality of life of advanced cancer patients, corrects deficiencies of vitamin C that often occur in cancer patients and optimizes white blood cell concentrations of vitamin C

Fat grafts commonly undergo ischemia and inflammation after transplantation, and most cells die within one week with only the ~ 300-m superficial layer surviving [8]

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