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Beyond the traditional M1-M2 paradigm, current transcriptomic analyses reveal greater TAM diversity with seven main subtypes: interferon-primed TAMs (IFN-TAMs), immune regulatory TAMs (Reg-TAMs), inflammatory cytokine-enriched TAMs (Inflam-TAMs), lipid-associated TAMs (LA-TAMs), proangiogenic TAMs (Angio-TAMs), RTM-like TAMs (RTM-TAMs), and proliferating TAMs (Prolif-TAMs) ( Figure 6 ) (94)
These changes dont just happen suddenly when you are older and it is important to maintain optimal B12 levels when you are younger
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