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Although rebound hyperammonaemia has also been reported with high-dose CKRT, this complication occurs to a lesser extent than in HD and does not require further KRT management

Abbreviations LC: L-carnitine TC: Total carnitine TMAO: Trimethylamine-N-oxide CHO: Carbohydrates IGF-1: Insulin-like growth factor-1 PI3K: Phosphoinositide-3-kinase Akt: Protein kinase B mTOR: Mammalian target of rapamycin S6K: S6 kinase 4E-BP: 4E-binding protein FoxO: Forkhead box O MuRF-1: Muscle-specific RING finger-1 atrogin-1: Muscle atrophy F-box mRNA: Messenger RNA BMI: Body mass index ROS: Reactive oxygen species References Bremer J

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Enkvist H, hman A, Pitknen M, Nordin M, Nordin S

10.1074/jbc.M213128200 12