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SmTGR Y296A was mixed with a range of NADPH concentrations and the reaction was monitored at 455 and 540 nm (Figures 7A,B)
However, in several cases the sulfonation reaction can lead to formation of a more active metabolite compared to the parent compound as is the case for the hair follicle stimulant minoxidil (Buhl et al., 1990) or the diuretic agent triamterene (Mutschler et al., 1983)
Stable in normal plasma, but can be prematurely cleaved in mildly reducing environments
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