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Curcumin likewise activates the Nrf2 pathway, which increases expression of antioxidant genes, and it inhibits lipid peroxidation and nitric oxide production in toxinbased PD models [22, 36]
HommelgaardAMRoepstorffKVilhardtFTorgersenMLSandvigKvan DeursB
Deamination of dopamine by monoaminoxidase (MAO) produces 3,4-dihydroxy-phenylacetaldehyde (DOPAL), an unstable and toxic oxidation product that can be easily oxidized by ALDH to the acidic metabolite 3,4-dihydroxyphenylacetic acid (DOPAC) [109,121]
Acta 473 , 8995 (2017)
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