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By in vitro and in vivo methods, it was found that these CD38-overexpressing M1-like macrophages are activated directly by inflammatory cytokines secreted by senescent cells (discussed in more detail later) 45,105,106

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doi: 10.1007/s00277-022-04917-5 51 BishtKFukaoTChironMRichardsonPAtanackovicDChiniEet al
Scacheri et al., 2004), as well as addressing the issues of sequence-dependent and chemical-dependent toxicity ( in vitro and animal studies, there are no reports of such products being utilized in clinical trials thus far