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In theory, they are complementary

Oridonin overcomes the gemcitabine resistant PANC-1/Gem cells by regulating GST pi and LRP/1 ERK/JNK signalling

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In summary, targeted therapy against these transport proteins may yield new insights into overcoming HGSOC drug resistance, and further research into their expression mechanisms and functions will facilitate the development of more effective treatment strategies

Use it to guide a conversation about fit, timing, and safety