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Tolcapone was the first COMT inhibitor to receive FDA approval, in 1998

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10.1016/j.ebiom.2022.104258 66 LvM.CaiY.HouW.PengK.XuK.LuC.et al (2022)

they suggested that these findings could be mediated by CYP and/or IR, which induce ROS overproduction, resulting in the inhibition of Nrf2 and its related cellular defense enzymes

Without baseline labs and a physician who understands your full health picture, youre making dosing decisions based on forum anecdotes rather than your own biology