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C., Yin, M

While GGT5 and GGT1 share 40% of the amino acid sequence (22), GGT5 is not as active in hydrolyzing GSH, GSSG and leukotriene C4 as GGT1 is (29)

Paradoxically, while normal prostate physiology prioritizes polyamine synthesis (e.g., spermine), regulated by androgen-dependent enzymes like ODC to support secretory functions, PCa progression exhibits a contradictory polyamine landscape: spermine levels decline sharply despite ODC overexpression, a phenomenon contrasting with polyamine accumulation patterns in other cancers

Therapeutic targeting of proteostasis in cancer Cancer cells are exposed to persistent proteotoxic stress driven by rapid proliferation, genomic instability, hypoxia, metabolic rewiring, and therapeutic pressure

This means Irish retailers and manufacturers cannot legally state that glutathione supplements "lighten skin," "detox the liver," or "improve immune function" as specific health claims on labelling or marketing materials