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The main focus of MMDD in treating PF is to reduce inflammatory cytokines, inhibit pro-fibrotic factors and oxidative stress, promote differentiation and homing of bone marrow mesenchymal stem cells, and enhance cell autophagy activity

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It counteracts both hypertension and hypotension in experimental models another example of its bidirectional "stabilizing" effect on physiological systems

This adapter also has a side arm connected to extension tubing that allows for continuous aspiration for blood and injection of solution by an assistant

Figure 3 illustrates the regulatory mechanism of the Keap1-Nrf2 signaling pathway